Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Fundamental Principles of Protein Engineering
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:25 pm
"Innovation by Evolution: Bringing New Chemistry to Life"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Protein Engineering: the Endless Frontier"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Engineering of Optical Biosensors to Illuminate the Biochemical Activity Architecture of the Cell"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Genetically Encoded Bioluminescent-Fluorescent Integrators of Cell Signaling Dynamics"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Biospecific Chemistry for Covalent Linking of Proteins with Biomacromolecules"
11:20 am - 11:25 am
Discussion
11:25 am - 11:55 am
"New Luciferases, Luciferins, and Bioluminescent Sensors"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Directed Evolution for Enzyme Optimization
7:30 pm - 8:00 pm
"When Directed Evolution Met Ancestral Enzyme Resurrection"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Protein Engineering for Enzymatic Oligomerization"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Extensive Protein Evolution on Laboratory Timescales"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Rational Design of New to Nature Proteins
9:00 am - 9:30 am
"Informing Rational Enzyme Design Using FAIR Practices"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Computational Design of Enzymes Through Coevolution and Correlation-Mediated Allosteric Networks"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Protein Engineering Using Consensus Information, Sequence Covariance and Machine Learning"
11:20 am - 11:25 am
Discussion
11:25 am - 11:55 am
"Exploring Novel Proteins via Rule-Based Approaches"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
AI for Protein Engineering
7:30 pm - 8:00 pm
"How AI is Influencing Protein Engineering"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Inverting Structure Predictions Model for Protein Design"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Functional Alignment of Protein Language Models with Reinforcement Learning"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Biocatalysis and Industrial Applications
9:00 am - 9:30 am
"Protein Engineering Unlocks Biocatalytic Processes for Drug Synthesis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Protein Engineering for Cascade Biocatalysis: Enantioselective Synthesis of Some Selected Chiral Chemicals"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Engineering Next-Generation Oxidative Biocatalysts in E.coli and P. pastoris "
11:20 am - 11:25 am
Discussion
11:25 am - 11:55 am
"Deep Learning-Guided Protein Directed Evolution"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Engineering for Synthetic Biology
7:30 pm - 8:00 pm
"From Code to Compound: Hacking Polyketide Synthases for Custom Chemistry"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Reprogramming Deaminase Specificity for Precise Genome Editing"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Enhance Synthetic Biology Using Machine-Guided Protein Engineering"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Protein Engineering for Immunotherapy and Other Diseases
9:00 am - 9:30 am
"Synthetic Receptor and Cas13 Circuits for Controlling Mammalian Cell Function"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"High-Throughput Mapping Immune Recognition by Synthetic Biology and Single-Cell Genomics"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Engineering CRISPR for Precision Medicine"
11:20 am - 11:25 am
Discussion
11:25 am - 11:55 am
"Bidirectional Tuning of CAR Signaling via a Functional Switch Motif"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Sonogenetic Engineering for Next-Generation CAR-T Cell Therapy"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Repurpose Proteins for Novel Chemistry and Applications
7:30 pm - 8:00 pm
"Unlocking New-to-Nature Transition Metal Catalysis in Nonheme Enzymes"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Next-Gen Genomically Recoded Organisms for Multi-Functionalization of Synthetic Proteins & Polymers"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Protein and Antibody Engineering Empowered by Uncertainty Aware AI/ML Models"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure